Targeting widespread sites of damage in dystrophic muscle: engrafted macrophages as potential shuttles.

@article{Parrish1996TargetingWS,
  title={Targeting widespread sites of damage in dystrophic muscle: engrafted macrophages as potential shuttles.},
  author={Esther Parrish and Carmen Cifuentes-D{\'i}az and Zhen Lin Li and Patrick Vicart and Denise Paulin and Patrick A. Dreyfus and Marc Peschanski and Aaron J Harris and Lourdes Garcia},
  journal={Gene therapy},
  year={1996},
  volume={3 1},
  pages={13-20}
}
Inherited muscle diseases are characterized by widespread muscle damage in the body. This limits the clinical relevance of cell or gene therapy based upon direct injections into muscles. One way to circumvent this obstacle would be to use circulating cells, capable of homing naturally to the sites of lesion, to deliver therapeutic substances. Certain muscular dystrophies present successive cycles of degeneration-regeneration. These sporadic necrotic lesions trigger local inflammations with… CONTINUE READING

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