Targeting virulence for antibacterial chemotherapy: identifying and characterising virulence factors for lead discovery.

Abstract

The antibacterial drug discovery industry is fast losing participants; at the same time it is facing the challenge of developing new antibiotics that are effective against frequently occurring and multiply resistant organisms. One intriguing approach is to target bacterial virulence, and the last decade or so has seen a focus on bacterial pathogenesis along… (More)

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