Targeting virulence: can we make evolution-proof drugs?

  title={Targeting virulence: can we make evolution-proof drugs?},
  author={Richard C. Allen and Roman Popat and Stephen P Diggle and Sam P. Brown},
  journal={Nature Reviews Microbiology},
Antivirulence drugs are a new type of therapeutic drug that target virulence factors, potentially revitalising the drug-development pipeline with new targets. As antivirulence drugs disarm the pathogen, rather than kill or halt pathogen growth, it has been hypothesized that they will generate much weaker selection for resistance than traditional antibiotics. However, recent studies have shown that mechanisms of resistance to antivirulence drugs exist, seemingly damaging the 'evolution-proof… CONTINUE READING
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