Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer.

  title={Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer.},
  author={Aaron M LeBeau and Sai Duriseti and Stephanie T. Murphy and François Pepin and Byron Hann and Joe W. Gray and Henry F. Vanbrocklin and Charles S. Craik},
  journal={Cancer research},
  volume={73 7},
Components of the plasminogen activation system, which are overexpressed in aggressive breast cancer subtypes, offer appealing targets for development of new diagnostics and therapeutics. By comparing gene expression data in patient populations and cultured cell lines, we identified elevated levels of the urokinase plasminogen activation receptor (uPAR, PLAUR) in highly aggressive breast cancer subtypes and cell lines. Recombinant human anti-uPAR antagonistic antibodies exhibited potent binding… CONTINUE READING
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