Targeting tyrosine kinases: a novel therapeutic strategy for systemic sclerosis.


PURPOSE OF REVIEW This article reviews the current evidence and rationale for the use of tyrosine kinase inhibitors as potential therapeutic interventions for systemic sclerosis. RECENT FINDINGS The signaling cascades of the profibrotic cytokines transforming growth factor-β and platelet-derived growth factor utilize tyrosine kinases. Preclinical studies… (More)
DOI: 10.1097/BOR.0b013e32833f1105


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