Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage

@inproceedings{Motolese2015TargetingTM,
  title={Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage},
  author={Marta Motolese and Federica Mastroiacovo and Milena Cannella and Domenico Bucci and Anderson Gaglione and Barbara Riozzi and Robert Johannes Luetjens and Sonia Maria Poli and Sylvain C{\'e}lanire and Valeria Bruno and Giuseppe Battaglia and Ferdinando Nicoletti},
  booktitle={Molecular Brain},
  year={2015}
}
BackgroundTo examine whether metabotropic glutamate (mGlu) receptors have any role in mechanisms that shape neuronal vulnerability to ischemic damage, we used the 4-vessel occlusion (4-VO) model of transient global ischemia in rats. 4-VO in rats causes a selective death of pyramidal neurons in the hippocampal CA1 region, leaving neurons of the CA3 region relatively spared. We wondered whether changes in the expression of individual mGlu receptor subtypes selectively occur in the vulnerable CA1… CONTINUE READING
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