Targeting tumor-stromal interactions in bone metastasis.

  title={Targeting tumor-stromal interactions in bone metastasis.},
  author={Mark Esposito and Yibin Kang},
  journal={Pharmacology & therapeutics},
  volume={141 2},
Bone metastasis is a frequent occurrence in late stage solid tumors, including breast cancers, prostate or lung. However, the causes for this proclivity have only recently been elucidated. Significant progress has been made in the past decade toward understanding the molecular underpinnings of bone metastasis, and much of this research reveals a crucial role of the host stroma in each step of the metastatic cascade. Tumor-stromal interactions are crucial in engineering a pre-metastatic niche… CONTINUE READING
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