Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor β

@article{Nagai2009TargetingTM,
  title={Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor β},
  author={Taku Nagai and Masashi Tanaka and Yasuhiro Tsuneyoshi and Baohui Xu and Sara A. Michie and Kazuhisa Hasui and Hirofumi Hirano and Kazunori Arita and Takami Matsuyama},
  journal={Cancer Immunology, Immunotherapy},
  year={2009},
  volume={58},
  pages={1577-1586}
}
Tumor-associated macrophages (TAMs) are frequently found in glioblastomas and a high degree of macrophage infiltration is associated with a poor prognosis for glioblastoma patients. However, it is unclear whether TAMs in glioblastomas promote tumor growth. In this study, we found that folate receptor β (FRβ) was expressed on macrophages in human glioblastomas and a rat C6 glioma implanted subcutaneously in nude mice. To target FRβ-expressing TAMs, we produced a recombinant immunotoxin… CONTINUE READING
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