Targeting tumor-associated macrophages as a novel strategy against breast cancer.

@article{Luo2006TargetingTM,
  title={Targeting tumor-associated macrophages as a novel strategy against breast cancer.},
  author={Yunping Luo and He Zhou and Joerg Krueger and Charles Kaplan and Sung-Hyung Lee and Carrie S. Dolman and Dorothy Markowitz and Wenyuan Wu and Cheng Liu and Ralph A. Reisfeld and Rong Xiang},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 8},
  pages={2132-2141}
}
Tumor-associated macrophages (TAMs) are associated with tumor progression and metastasis. Here, we demonstrate for the first time that legumain, a member of the asparaginyl endopeptidase family functioning as a stress protein, overexpressed by TAMs, provides an ideal target molecule. In fact, a legumain-based DNA vaccine served as a tool to prove this point, as it induced a robust CD8+ T cell response against TAMs, which dramatically reduced their density in tumor tissues and resulted in a… CONTINUE READING