Targeting tumor-associated carbonic anhydrase IX in cancer therapy.

Abstract

Carbonic anhydrase isoform IX (CA IX) is highly overexpressed in many types of cancer. Its expression, which is regulated by the HIF-1 transcription factor, is strongly induced by hypoxia and correlates with a poor response to classical chemo- and radiotherapies. CA IX contributes to acidification of the tumor environment by efficiently catalyzing the… (More)

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Cite this paper

@article{Thiry2006TargetingTC, title={Targeting tumor-associated carbonic anhydrase IX in cancer therapy.}, author={Anne Thiry and J M Dogn{\'e} and Bernard Masereel and Claudiu T. Supuran}, journal={Trends in pharmacological sciences}, year={2006}, volume={27 11}, pages={566-73} }