Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy.

@article{Li2010TargetingTF,
  title={Targeting transcription factor NF-kappaB to overcome chemoresistance and radioresistance in cancer therapy.},
  author={Feng Li and Gautam Sethi},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1805 2},
  pages={
          167-80
        }
}
Activation of transcription factor NF-kappaB is frequently encountered in tumor cells and contributes to aggressive tumor growth and resistance to chemotherapy and ionizing radiation during cancer treatment. Accumulating evidence over the last few years indicate that most chemotherapeutic agents and radiation therapy activate NF-kappaB in vitro and in vivo. Moreover, induction of chemoresistance and radioresistance is mediated through several genes regulated by NF-kappaB and inhibition of this… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 241 CITATIONS, ESTIMATED 52% COVERAGE

Chemoprevention in gastrointestinal physiology and disease. Anti-inflammatory approaches for colorectal cancer chemoprevention.

  • American journal of physiology. Gastrointestinal and liver physiology
  • 2015
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

NF-κB in cancer therapy

  • Archives of Toxicology
  • 2015
VIEW 8 EXCERPTS
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 14 Highly Influenced Citations

  • Averaged 29 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 266 REFERENCES

Enhanced chemosensitivity to irinotecan by RNA interference-mediated down-regulation of the nuclear factor-kappaB p65 subunit.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2004
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

R

J. U. Lee
  • Hosotani, M.Wada, R. Doi, T. Kosiba, K. Fujimoto, Y. Miyamoto, S. Tsuji, S. Nakajima, Y. Nishimura, M. Imamura, Role of Bcl-2 family proteins (Bax, Bcl-2 and Bcl-X) on cellular susceptibility to radiation in pancreatic cancer cells, Eur. J. Cancer 35
  • 1999
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Small inhibitor of Bcl- 2

E. D. Arisan, O. Kutuk, +3 authors H. Basaga
  • HA14-1, selectively enhanced the apoptotic effect of cisplatin by modulating Bcl-2 family members in MDA-MB-231 breast cancer cells, Breast Cancer Res. Treat. 119
  • 2010
VIEW 1 EXCERPT