Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances anti-tumor responses of peripheral blood mononuclear cells from human lung cancer patients.

@article{Ren2008TargetingTR,
  title={Targeting toll-like receptor 9 with CpG oligodeoxynucleotides enhances anti-tumor responses of peripheral blood mononuclear cells from human lung cancer patients.},
  author={Tao Ren and Zhen-ke Wen and Zhongmin Liu and Cheng Qian and Yong-Jie Liang and Mei-ling Jin and Ying-yun Cai and Ling Xu},
  journal={Cancer investigation},
  year={2008},
  volume={26 5},
  pages={448-55}
}
CpG-oligonucleotides (CpG-ODN), which induce signaling through Toll-like receptor 9 (TLR9), are currently under investigation as adjuvants in therapy against infections and cancer. However, whether the CpG-ODN alone could enhance the anti-tumor immunity and the underlying mechanisms remains unclear. Here, we investigated that stimulation of peripheral blood mononuclear cells (PBMCs) from human lung cancer patients with CpG-ODN induced proliferation responses of the PBMCs, accompanied by the… CONTINUE READING
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