Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis.

@article{Hellwig2001TargetingTF,
  title={Targeting to Fcgamma receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis.},
  author={Sandra M. M. Hellwig and H F van Oirschot and Wouter L. W. Hazenbos and Annemiek B van Spriel and Frits R. Mooi and Jan G. J. van de Winkel},
  journal={The Journal of infectious diseases},
  year={2001},
  volume={183 6},
  pages={871-9}
}
In the absence of opsonizing antibodies, Bordetella pertussis, the causative agent of pertussis, readily binds to phagocytes via complement receptor 3 (CR3). After opsonization with antibodies, binding is mediated by IgG receptors (FcgammaR). The effect of targeting B. pertussis to either FcgammaR or CR3 was studied. The fate of unopsonized B. pertussis, IgG-opsonized B. pertussis, and B. pertussis opsonized with bispecific antibodies (BsAbs) directed to CR3 or FcgammaRII/-III was compared. IgG… CONTINUE READING
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