Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations

@inproceedings{Hu2013TargetingTM,
  title={Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations},
  author={Fang Hu and Feng Liu},
  booktitle={Protein & Cell},
  year={2013}
}
It has been well established that most of the age-related diseases such as insulin resistance, type 2 diabetes, hypertension, cardiovascular disease, osteoporosis, and atherosclerosis are all closely related to metabolic dysfunction. On the other hand, interventions on metabolism such as calorie restriction or genetic manipulations of key metabolic signaling pathways such as the insulin and mTOR signaling pathways slow down the aging process and improve healthy aging. These findings raise an… CONTINUE READING

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