Targeting the ubiquitin-proteasome pathway: an emerging concept in cancer therapy.

  title={Targeting the ubiquitin-proteasome pathway: an emerging concept in cancer therapy.},
  author={Michael Joseph Frezza and Sara M. Schmitt and Q Ping Dou},
  journal={Current topics in medicinal chemistry},
  volume={11 23},
Selective degradation of proteins by the ubiquitin-proteasome pathway is a critical determinant for maintaining cellular homeostasis. Most intracellular proteins are degraded by the proteasome, a multicatalytic enzyme complex containing a 20S catalytic core and two 19S regulatory complexes. Many proteasome target proteins are involved in the regulation of important processes of carcinogenesis and cancer cell survival, such as cell cycle progression, cell proliferation, differentiation and… CONTINUE READING


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