Targeting the translation machinery in cancer


Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and tumour suppressors affect the translation machinery, making aberrant translation a widespread characteristic of tumour cells, independent of the genetic make-up of the cancer. Therefore, therapeutic agents that target components of the protein synthesis apparatus hold… (More)
DOI: 10.1038/nrd4505


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@article{Bhat2015TargetingTT, title={Targeting the translation machinery in cancer}, author={Mamatha Bhat and Nathaniel Robichaud and Laura Hulea and Nahum Sonenberg and Jerry Pelletier and Ivan Topisirovic}, journal={Nature Reviews Drug Discovery}, year={2015}, volume={14}, pages={261-278} }