Targeting the thrombin receptor modulates inflammation and astrogliosis to improve recovery after spinal cord injury.

Abstract

The deregulation of serine protease activity is a common feature of neurological injury, but little is known regarding their mechanisms of action or whether they can be targeted to facilitate repair. In this study we demonstrate that the thrombin receptor (Protease Activated Receptor 1, (PAR1)) serves as a critical translator of the spinal cord injury (SCI… (More)
DOI: 10.1016/j.nbd.2016.04.010

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