Targeting the systemic exposure of teniposide in the population and the individual using a stochastic therapeutic objective

@article{DArgenio1993TargetingTS,
  title={Targeting the systemic exposure of teniposide in the population and the individual using a stochastic therapeutic objective},
  author={David Z. D'Argenio and John H. Rodman},
  journal={Journal of Pharmacokinetics and Biopharmaceutics},
  year={1993},
  volume={21},
  pages={223-251}
}
A stochastic control approach for dose regimen design is developed and applied to the problem of targeting the systemic exposure, defined as the area under the blood concentrationtime curve (AUC),of the anticancer drug teniposide in both the population and individual patients. The control objective involves maximizing the probability that AUCis within a selected target interval given either the population distribution for the kinetic model parameters (a priori control) or the posterior… CONTINUE READING

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