Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.

@article{Akhter1998TargetingTR,
  title={Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.},
  author={Shamima Akhter and Louis M. Luttrell and Howard A Rockman and Guido Iaccarino and Robert J Lefkowitz and Walter J Koch},
  journal={Science},
  year={1998},
  volume={280 5363},
  pages={574-7}
}
Hormones and neurotransmitters may mediate common responses through receptors that couple to the same class of heterotrimeric guanine nucleotide-binding (G) protein. For example, several receptors that couple to Gq class proteins can induce cardiomyocyte hypertrophy. Class-specific inhibition of Gq-mediated signaling was produced in the hearts of transgenic mice by targeted expression of a carboxyl-terminal peptide of the alpha subunit Galphaq. When pressure overload was surgically induced, the… CONTINUE READING