Targeting the production of oncogenic microRNAs with multimodal synthetic small molecules.

  title={Targeting the production of oncogenic microRNAs with multimodal synthetic small molecules.},
  author={Duc Duy Vo and Cathy Staedel and Laura Zehnacker and Rachid Benhida and Fabien Darfeuille and Maria Duca},
  journal={ACS chemical biology},
  volume={9 3},
MicroRNAs (miRNAs) are a recently discovered category of small RNA molecules that regulate gene expression at the post-transcriptional level. Accumulating evidence indicates that miRNAs are aberrantly expressed in a variety of human cancers and revealed to be oncogenic and to play a pivotal role in initiation and progression of these pathologies. It is now clear that the inhibition of oncogenic miRNAs, defined as blocking their biosynthesis or their function, could find an application in the… CONTINUE READING
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