Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside.

@article{Martelli2007TargetingTP,
  title={Targeting the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin module for acute myelogenous leukemia therapy: from bench to bedside.},
  author={Alberto Maria Martelli and Pier Luigi Tazzari and Camilla Evangelisti and Francesca Chiarini and William L. Blalock and Anna Maria Billi and Lucia Manzoli and James A McCubrey and Lucio Cocco},
  journal={Current medicinal chemistry},
  year={2007},
  volume={14 19},
  pages={
          2009-23
        }
}
The phosphatidylinositol 3-kinase (PI3K)/Akt (protein kinase B, PKB)/mammalian Target Of Rapamycin (mTOR) signaling pathway plays a critical role in many cellular functions which are elicited by extracellular stimuli. However, constitutively active PI3K/Akt/mTOR signaling has also been firmly established as a major determinant for cell growth, proliferation, and survival in an wide array of human cancers. Thus, blocking the PI3K/AKT/mTOR signal transduction network could be an effective new… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway

Journal of experimental & clinical cancer research : CR • 2008
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…