Targeting the p38 MAPK pathway inhibits irinotecan resistance in colon adenocarcinoma.

  title={Targeting the p38 MAPK pathway inhibits irinotecan resistance in colon adenocarcinoma.},
  author={Salom{\'e} Paillas and Florence Boissi{\'e}re and Fr{\'e}d{\'e}ric Bibeau and Am{\'e}lie Denouel and Caroline Mollevi and Annick Causse and Vincent Denis and Nadia Vezzio-Vi{\'e} and Laetitia Marzi and C{\'e}dric Cortijo and Imade Ait-Arsa and Nadav Askari and Philippe Pourquier and P. Martineau and Maguy del Rio and C{\'e}line Gongora},
  journal={Cancer research},
  volume={71 3},
Despite recent advances in the treatment of colon cancer, tumor resistance is a frequent cause of chemotherapy failure. To better elucidate the molecular mechanisms involved in resistance to irinotecan (and its active metabolite SN38), we established SN38-resistant clones derived from HCT-116 and SW48 cell lines. These clones show various levels (6- to 60-fold) of resistance to SN-38 and display enhanced levels of activated MAPK p38 as compared with the corresponding parental cells. Because… CONTINUE READING


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