Targeting the nucleus: an overview of Auger-electron radionuclide therapy.

  title={Targeting the nucleus: an overview of Auger-electron radionuclide therapy.},
  author={B. M. Cornelissen and Katherine Anne Vallis},
  journal={Current drug discovery technologies},
  volume={7 4},
The review presented here lays out the present state of the art in the field of radionuclide therapies specifically targeted against the nucleus of cancer cells, focussing on the use of Auger-electron-emitters. Nuclear localisation of radionuclides increases DNA damage and cell kill, and, in the case of Auger-electron therapy, is deemed necessary for therapeutic effect. Several strategies will be discussed to direct radionuclides to the nucleoplasm, even to specific protein targets within the… CONTINUE READING


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