Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses.

@article{Gurer2008TargetingTN,
  title={Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses.},
  author={Cagan Gurer and Till Strowig and Fabienne Brilot and Maggi Pack and Christine Marie Trumpfheller and Frida Arrey and Chae Gyu Park and Ralph M. Steinman and Christian M{\"u}nz},
  journal={Blood},
  year={2008},
  volume={112 4},
  pages={
          1231-9
        }
}
Dendritic cells (DCs) express many endocytic receptors that deliver antigens for major histocompatibility class (MHC) I and II presentation to CD8(+) and CD4(+) T cells, respectively. Here, we show that targeting Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) to one of them, the human multilectin DEC-205 receptor, in the presence of the DC maturation stimulus poly(I:C), expanded EBNA1-specific CD4(+) and CD8(+) memory T cells, and these lymphocytes could control the outgrowth of autologous… CONTINUE READING

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