Targeting the murine serotonin transporter: insights into human neurobiology

  title={Targeting the murine serotonin transporter: insights into human neurobiology},
  author={D. Murphy and K. Lesch},
  journal={Nature Reviews Neuroscience},
  • D. Murphy, K. Lesch
  • Published 2008
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • Mutations resulting in reduced or completely abrogated serotonin-transporter (SERT) function in mice have led to the identification of more than 50 different phenotypic changes, ranging from increased anxiety and stress-related behaviours to gut dysfunction, bone weakness and late-onset obesity with metabolic syndrome. These multiple effects, which can be amplified by gene–environment and gene–gene interactions, are primarily attributable to altered intracellular and extracellular serotonin… CONTINUE READING
    387 Citations

    Figures and Topics from this paper.

    Paper Mentions

    Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes
    • 178
    • Highly Influenced
    • PDF
    Lack of Serotonin Transporter Alters BDNF Expression in the Rat Brain During Early Postnatal Development
    • 32
    Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes
    • 69
    • PDF
    Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice
    • 33
    • PDF
    The serotonin transporter gene and functional and pathological adaptation to environmental variation across the life span
    • 44


    Cellular and molecular alterations in mice with deficient and reduced serotonin transporters
    • Q. Li
    • Biology, Medicine
    • Molecular Neurobiology
    • 2007
    • 43
    Serotonin transporter: gene, genetic disorders, and pharmacogenetics.
    • 404
    The developmental role of serotonin: news from mouse molecular genetics
    • 1,048
    • PDF
    Genetic perspectives on the serotonin transporter
    • 192
    • PDF