Targeting the murine serotonin transporter: insights into human neurobiology

  title={Targeting the murine serotonin transporter: insights into human neurobiology},
  author={Dennis L. Murphy and Klaus-Peter Lesch},
  journal={Nature Reviews Neuroscience},
Mutations resulting in reduced or completely abrogated serotonin-transporter (SERT) function in mice have led to the identification of more than 50 different phenotypic changes, ranging from increased anxiety and stress-related behaviours to gut dysfunction, bone weakness and late-onset obesity with metabolic syndrome. These multiple effects, which can be amplified by gene–environment and gene–gene interactions, are primarily attributable to altered intracellular and extracellular serotonin… CONTINUE READING
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