Targeting the mTOR pathway in tumor malignancy.


The mammalian target of rapamycin (mTOR) plays a critical role in the regulation of cell growth, proliferation,and metabolism by integrating growth factor stimulation and energy/nutrient input through a complex signaling network.The mTOR kinase is a part of two structurally and functionally distinct multiple protein complexes, mTORC1 and mTORC2. The… (More)


Cite this paper

@article{Cheng2013TargetingTM, title={Targeting the mTOR pathway in tumor malignancy.}, author={Hengmiao Cheng and Marlena Walls and Sangita M. Baxi and M. S. Yin}, journal={Current cancer drug targets}, year={2013}, volume={13 3}, pages={267-77} }