Targeting the mTOR kinase domain: the second generation of mTOR inhibitors.

@article{Zhang2011TargetingTM,
  title={Targeting the mTOR kinase domain: the second generation of mTOR inhibitors.},
  author={Yan-jie Zhang and Yanwen Duan and X. F. Steven Zheng},
  journal={Drug discovery today},
  year={2011},
  volume={16 7-8},
  pages={325-31}
}
The mTOR signaling pathway is dysregulated in ∼50% of all human malignancies and is a major cancer drug target. Although rapamycin analogs (rapalogs) have shown clinical efficacy in a subset of cancers, they do not fully exploit the antitumor potential of mTOR targeting. Because the mTOR kinase domain is important for rapamycin-sensitive and -insensitive functions, mTOR catalytic inhibitors have been developed recently as the second generation of anti-mTOR agents. Importantly, they have shown… CONTINUE READING

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