Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis.

@article{OsbornHeaford2015TargetingTI,
  title={Targeting the isoprenoid pathway to abrogate progression of pulmonary fibrosis.},
  author={Heather L Osborn-Heaford and S. Murthy and L. Gu and J. L. Larson-Casey and A. Ryan and Lei Shi and M. Glogauer and Jeffrey D Neighbors and R. Hohl and A. Carter},
  journal={Free radical biology \& medicine},
  year={2015},
  volume={86},
  pages={
          47-56
        }
}
Fibrotic remodeling in lung injury is a major cause of morbidity. The mechanism that mediates the ongoing fibrosis is unclear, and there is no available treatment to abate the aberrant repair. Reactive oxygen species (ROS) have a critical role in inducing fibrosis by modulating extracellular matrix deposition. Specifically, mitochondrial hydrogen peroxide (H2O2) production by alveolar macrophages is directly linked to pulmonary fibrosis as inhibition of mitochondrial H2O2 attenuates the… Expand
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