Targeting the insulin-like growth factor signaling pathway: figitumumab and other novel anticancer strategies.

@article{Yap2011TargetingTI,
  title={Targeting the insulin-like growth factor signaling pathway: figitumumab and other novel anticancer strategies.},
  author={Timothy A Yap and David R Olmos and Lulama Rhoda Molife and Johann S de Bono},
  journal={Expert opinion on investigational drugs},
  year={2011},
  volume={20 9},
  pages={1293-304}
}
INTRODUCTION There are clear preclinical data that support the involvement of the insulin-like growth factor (IGF) signaling pathway in oncogenesis and cancer progression. Such evidence has led to the design and conduct of drug development programs targeting the IGF-I receptor (IGF-IR) over the past 10 years. AREAS COVERED This review details the structure and function of different members of the IGF system and related pathways, describes the rationale for targeting IGF-IR in cancer and… CONTINUE READING

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