Targeting the epidermal growth factor receptor in metastatic colorectal cancer.

@article{Ng2008TargetingTE,
  title={Targeting the epidermal growth factor receptor in metastatic colorectal cancer.},
  author={Kimmie Ng and Andrew X. Zhu},
  journal={Critical reviews in oncology/hematology},
  year={2008},
  volume={65 1},
  pages={8-20}
}
Although significant advances have been made in the treatment of metastatic colorectal cancer (CRC), prognosis remains poor, with a 5-year survival of less than 10%. Monoclonal antibodies that target the epidermal growth factor receptor (EGFR) have shown clinical benefit as single agents and in combination with standard chemotherapy in the refractory setting, with tolerable toxicity. This article will discuss the role of the EGFR pathway in the pathogenesis of CRC, the data supporting the… CONTINUE READING

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