Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage.

@article{Kari2003TargetingTE,
  title={Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage.},
  author={Csaba Kari and Tung O. Chan and Marlene Rocha de Quadros and Ulrich Rodeck},
  journal={Cancer research},
  year={2003},
  volume={63 1},
  pages={1-5}
}
Aberrant activation of the epidermal growth factor receptor (EGFR) is frequently observed in neoplasia,notably in tumors of epithelial origin. Attempts to treat such tumors with EGFR antagonists have met with remarkable initial successes, particularly when EGFR antagonists were used in combination with chemotherapy or ionizing radiation. Considering the almost ubiquitous expression of the EGFR in normal epithelial tissues, these clinical trials also revealed a surprisingly low rate of adverse… CONTINUE READING
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