Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab

@inproceedings{Chen2012TargetingTE,
  title={Targeting the epidermal growth factor receptor in non-small cell lung cancer cells: the effect of combining RNA interference with tyrosine kinase inhibitors or cetuximab},
  author={Gang Chen and Peter Kronenberger and Erik Teugels and Ijeoma Adaku Umelo and Jacques L P De Gr{\`e}ve},
  booktitle={BMC medicine},
  year={2012}
}
BACKGROUND The epidermal growth factor receptor (EGFR) is a validated therapeutic target in non-small cell lung cancer (NSCLC). However, current single agent receptor targeting does not achieve a maximal therapeutic effect, and some mutations confer resistance to current available agents. In the current study we have examined, in different NSCLC cell lines, the combined effect of RNA interference targeting the EGFR mRNA, and inactivation of EGFR signaling using different receptor tyrosine… CONTINUE READING
BETA
Highly Cited
This paper has 103 citations. REVIEW CITATIONS
Tweets
This paper has been referenced on Twitter 6 times. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 58 CITATIONS, ESTIMATED 56% COVERAGE

103 Citations

0102030'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 103 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 65 REFERENCES

Similar Papers

Loading similar papers…