Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats

@article{Gal2003TargetingTD,
  title={Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats},
  author={Krisztina Gál and Istv{\'a}n Gyerty{\'a}n},
  journal={Brain Research Bulletin},
  year={2003},
  volume={61},
  pages={595-601}
}
The Novel Dopamine D3 Receptor Antagonist NGB 2904 Inhibits Cocaine's Rewarding Effects and Cocaine-Induced Reinstatement of Drug-Seeking Behavior in Rats
TLDR
The data show that the novel D3-selective antagonist NGB 2904 attenuates cocaine's rewarding effects as assessed by PR self-administration, BSR, and cocaine-triggered reinstatement of cocaine-seeking behavior.
Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction.
TLDR
The data reviewed in this paper suggest that NGB 2904 or other D3-selective antagonists may have potential in controlling motivation for drug-taking behavior or relapse to drug-seeking behavior, but may have a limited role in antagonizing the acute rewarding effects produced by cocaine or other addictive drugs.
Cocaine self-administration in dopamine D₃ receptor knockout mice.
TLDR
The present data do not support a necessary role for the D₃ receptor in the direct reinforcing effects of cocaine, and effects with cocaine self-administration were more subtle than the lower responding of D ₃ knockout mice observed with food-maintained behavior.
Dopamine D1 and D3 Receptor Polypharmacology in Cocaine Reward and Cocaine Seeking
TLDR
The aims of this dissertation were to evaluate the effects of the novel strategy of simultaneous treatments with a D3 receptor antagonist and D1 receptor partial agonist in animal models of drug addiction, including cue-induced reinstatement of cocaine seeking, cocaine conditioned place preference (CPP) and cocaine self-administration in rats.
Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats
TLDR
This study compared acute and chronic effects of dopamine D2- and D3-preferring ligands on choice between intravenous cocaine and palatable food in rats and showed distinct profiles, consistent with different pharmacological actions.
Dopamine D1 and D3 receptor interactions in cocaine reward and seeking in rats
TLDR
The results indicate that the combined treatment with a D1 receptor partial agonist and D3 receptor antagonist produces robust decreases in cocaine seeking and reward, which suggests an interaction between dopamine D1 and D2 receptors in cocaine-related behaviors.
Reduction of Cocaine Self-Administration and D3 Receptor-Mediated Behavior by Two Novel Dopamine D3 Receptor-Selective Partial Agonists, OS-3-106 and WW-III-55
TLDR
Findings support D3Rs, and possibly D2Rs, as targets for medications aimed at reducing the motivation to seek cocaine.
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Three dopamine receptor agonists had affinities for binding to the D-3 receptor that correlated highly with their relative potencies in decreasing cocaine self-administration in the rat at doses that were not by themselves reinforcing.
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Cocaine-maintained responding varied as a function of dose and was characterized as an inverted U-shaped function, while cocaine intake increased in a dose-related fashion, while D3 receptor antagonists are more likely to selectively decrease intake relative to response rates than D2 receptor antagonists.
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An important role for D3 receptors in mediating the addictive properties of cocaine is suggested and blockade of dopamine D3receptors may constitute a new and useful target for prospective pharmacotherapies for cocaine addiction.
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TLDR
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