Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats
@article{Gal2003TargetingTD, title={Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats}, author={Krisztina Gál and Istv{\'a}n Gyerty{\'a}n}, journal={Brain Research Bulletin}, year={2003}, volume={61}, pages={595-601} }
50 Citations
The preferential dopamine D3 receptor antagonist S33138 inhibits cocaine reward and cocaine-triggered relapse to drug-seeking behavior in rats
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The Novel Dopamine D3 Receptor Antagonist NGB 2904 Inhibits Cocaine's Rewarding Effects and Cocaine-Induced Reinstatement of Drug-Seeking Behavior in Rats
- Biology, PsychologyNeuropsychopharmacology
- 2006
The data show that the novel D3-selective antagonist NGB 2904 attenuates cocaine's rewarding effects as assessed by PR self-administration, BSR, and cocaine-triggered reinstatement of cocaine-seeking behavior.
Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction.
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The data reviewed in this paper suggest that NGB 2904 or other D3-selective antagonists may have potential in controlling motivation for drug-taking behavior or relapse to drug-seeking behavior, but may have a limited role in antagonizing the acute rewarding effects produced by cocaine or other addictive drugs.
Cocaine self-administration in dopamine D₃ receptor knockout mice.
- Biology, PsychologyExperimental and clinical psychopharmacology
- 2012
The present data do not support a necessary role for the D₃ receptor in the direct reinforcing effects of cocaine, and effects with cocaine self-administration were more subtle than the lower responding of D ₃ knockout mice observed with food-maintained behavior.
Dopamine D3 as well as D2 receptor ligands attenuate the cue-induced cocaine-seeking in a relapse model in rats.
- Psychology, BiologyDrug and alcohol dependence
- 2006
Dopamine D1 and D3 Receptor Polypharmacology in Cocaine Reward and Cocaine Seeking
- Biology, Psychology
- 2017
The aims of this dissertation were to evaluate the effects of the novel strategy of simultaneous treatments with a D3 receptor antagonist and D1 receptor partial agonist in animal models of drug addiction, including cue-induced reinstatement of cocaine seeking, cocaine conditioned place preference (CPP) and cocaine self-administration in rats.
Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats
- Biology, PsychologyThe Journal of Pharmacology and Experimental Therapeutics
- 2017
This study compared acute and chronic effects of dopamine D2- and D3-preferring ligands on choice between intravenous cocaine and palatable food in rats and showed distinct profiles, consistent with different pharmacological actions.
Dopamine D1 and D3 receptor interactions in cocaine reward and seeking in rats
- Biology, PsychologyPsychopharmacology
- 2016
The results indicate that the combined treatment with a D1 receptor partial agonist and D3 receptor antagonist produces robust decreases in cocaine seeking and reward, which suggests an interaction between dopamine D1 and D2 receptors in cocaine-related behaviors.
Reduction of Cocaine Self-Administration and D3 Receptor-Mediated Behavior by Two Novel Dopamine D3 Receptor-Selective Partial Agonists, OS-3-106 and WW-III-55
- Biology, PsychologyThe Journal of Pharmacology and Experimental Therapeutics
- 2013
Findings support D3Rs, and possibly D2Rs, as targets for medications aimed at reducing the motivation to seek cocaine.
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- 2011
References
SHOWING 1-10 OF 37 REFERENCES
Dopamine D2/D3 receptors modulate cocaine's reinforcing and discriminative stimulus effects in rhesus monkeys.
- Biology, PsychologyDrug and alcohol dependence
- 1999
Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.
- Biology, PsychologyScience
- 1993
Three dopamine receptor agonists had affinities for binding to the D-3 receptor that correlated highly with their relative potencies in decreasing cocaine self-administration in the rat at doses that were not by themselves reinforcing.
The effects of benzamide analogues on cocaine self-administration in rhesus monkeys
- Biology, MedicinePsychopharmacology
- 1999
Cocaine-maintained responding varied as a function of dose and was characterized as an inverted U-shaped function, while cocaine intake increased in a dose-related fashion, while D3 receptor antagonists are more likely to selectively decrease intake relative to response rates than D2 receptor antagonists.
Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats
- Biology, PsychologyThe Journal of Neuroscience
- 2002
An important role for D3 receptors in mediating the addictive properties of cocaine is suggested and blockade of dopamine D3receptors may constitute a new and useful target for prospective pharmacotherapies for cocaine addiction.
Cocaine-induced locomotor activity and cocaine discrimination in dopamine D4 receptor mutant mice
- Psychology, BiologyPsychopharmacology
- 2003
The present results on the stimulation of activity and interoceptive/subjective effects of cocaine are consistent with the previously reported disregulation of dopamine synthesis in DA D4R KO mice, and further suggest a role of the DA D 4R in vulnerability to stimulant abuse.
Dopamine D3 receptor ligands show place conditioning effect but do not influence cocaine-induced place preference
- Biology, PsychologyNeuroreport
- 2003
Results suggest the D3-preferring agonists could affect the reward mechanisms of the brain, however, modulation of D3 receptor function does not appear to be a significant mechanism for modifying the place conditioning effect of cocaine.
Dopamine D3 receptor agents as potential new medications for drug addiction
- Biology, PsychologyEuropean Psychiatry
- 2000
D3 receptor test in vitro predicts decreased cocaine self‐administration in rats
- Biology, PsychologyNeuroreport
- 1997
The hypothesis that the D3 receptor may be an important target for pharmacotherapies for cocaine abuse and dependence is supported.
Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist
- Biology, PsychologyNature
- 1999
BP 897 inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects, which indicates that compounds like BP 897 could be used for reducing the drug craving and vulnerability to relapse that are elicited by drug- associated environmental stimuli.
Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists
- Biology, PsychologyThe Journal of Neuroscience
- 2002
It is suggested that the D2 receptor is not necessary for cocaine self-administration, but this receptor subtype is involved in mechanisms that limit rates of high-dose cocaine self–administration.