Targeting the chromatin-remodeling MSL complex of Drosophila to its sites of action on the X chromosome requires both acetyl transferase and ATPase activities.

@article{Gu2000TargetingTC,
  title={Targeting the chromatin-remodeling MSL complex of Drosophila to its sites of action on the X chromosome requires both acetyl transferase and ATPase activities.},
  author={Wanjun Gu and Xiaomu Wei and Antonio Pannuti and John C. Lucchesi},
  journal={The EMBO journal},
  year={2000},
  volume={19 19},
  pages={5202-11}
}
Dosage compensation in Drosophila is mediated by a multiprotein, RNA-containing complex that associates with the X chromosome at multiple sites. We have investigated the role that the enzymatic activities of two complex components, the histone acetyltransferase activity of MOF and the ATPase activity of MLE, may have in the targeting and association of the complex with the X chromosome. Here we report that MLE and MOF activities are necessary for complexes to access the various X chromosome… CONTINUE READING

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