Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer

Abstract

Increased collagen expression in tumors is associated with increased risk of metastasis, and triple-negative breast cancer (TNBC) has the highest propensity to develop distant metastases when there is evidence of central fibrosis. Transforming growth factor-β (TGF-β) ligands regulated by cancer-associated fibroblasts (CAFs) promote accumulation of fibrosis… (More)
DOI: 10.18632/oncotarget.12658

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5 Figures and Tables