Targeting the brain with PEG-PLGA nanoparticles modified with phage-displayed peptides.

@article{Li2011TargetingTB,
  title={Targeting the brain with PEG-PLGA nanoparticles modified with phage-displayed peptides.},
  author={Jingwei Li and Liang Feng and Li Yan Fan and Yuan yuan Zha and Liangran Guo and Qizhi Zhang and Jun Chen and Zhiqing Pang and Yuchen Wang and Xinguo Jiang and Victor C Yang and Longping Wen},
  journal={Biomaterials},
  year={2011},
  volume={32 21},
  pages={
          4943-50
        }
}
The relative impermeability of the blood-brain barrier (BBB) results from tight junctions and efflux transport systems limits drug delivery to the central nervous system (CNS), and thus severely restricts the therapy of many central nervous system diseases. In order to enhance the brain-specific drug delivery, we employed a 12-mer phage display peptide library to isolate peptides that could target the drug delivery system to the brain. A 12-amino-acid-peptide (denoted as Pep TGN) which was… CONTINUE READING
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