Targeting the anthrax receptors, TEM-8 and CMG-2, for anti-angiogenic therapy.

@article{Cryan2011TargetingTA,
  title={Targeting the anthrax receptors, TEM-8 and CMG-2, for anti-angiogenic therapy.},
  author={Lorna M Cryan and Michael S. Rogers},
  journal={Frontiers in bioscience},
  year={2011},
  volume={16},
  pages={1574-88}
}
The anthrax toxin receptors tumor endothelial marker-8 (TEM-8) and capillary morphogenesis gene-2 (CMG-2) are responsible for allowing entry of anthrax toxin into host cells. These receptors were first discovered due to their enhanced expression on endothelial cells undergoing blood vessel growth or angiogenesis in model systems. Inhibition of angiogenesis is an important strategy for current anti-cancer therapies and treatment of retinal diseases. Functional roles for TEM-8 and CMG-2 in… CONTINUE READING