Targeting the alpha9alpha10 nicotinic acetylcholine receptor to treat severe pain.

@article{Vincler2007TargetingTA,
  title={Targeting the alpha9alpha10 nicotinic acetylcholine receptor to treat severe pain.},
  author={Michelle A. Vincler and John McIntosh},
  journal={Expert opinion on therapeutic targets},
  year={2007},
  volume={11 7},
  pages={891-7}
}
The alpha9alpha10 nicotinic acetylcholine receptors (nAChRs) are recognized for their function in the hair cells of the inner ear; transcripts for a9 and/or a10 subunits have also been identified in a diverse range of other tissues , including immune cells. The functioning of alpha9alpha10 nAChRs in these latter tissues is unknown. However, a recent series of studies has provided evidence that blockade of the alpha9alpha10 nAChR can alleviate chronic pain resulting from overt peripheral nerve… CONTINUE READING

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