Targeting the Wnt pathways for therapies

@inproceedings{Blagodatski2014TargetingTW,
  title={Targeting the Wnt pathways for therapies},
  author={Artem S Blagodatski and Dmitry A Poteryaev and Vladimir L Katanaev},
  booktitle={Molecular and Cellular Therapies},
  year={2014}
}
The Wnt/β-catenin signaling pathway is crucial in animal development from sponges to humans. Its activity in the adulthood is less general, with exceptions having huge medical importance. Namely, improper activation of this pathway is carcinogenic in many tissues, most notably in the colon, liver and the breast. On the other hand, the Wnt/β-catenin signaling must be re-activated in cases of tissue damage, and insufficient activation results in regeneration failure and degeneration. These both… CONTINUE READING
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