Targeting the WEE1 kinase as a molecular targeted therapy for gastric cancer

@inproceedings{Kim2016TargetingTW,
  title={Targeting the WEE1 kinase as a molecular targeted therapy for gastric cancer},
  author={Hye-Young Kim and Yunhee Cho and HyeokGu Kang and Ye-Seal Yim and Seok-Jun Kim and Jaewhan Song and K. W. Chun},
  booktitle={Oncotarget},
  year={2016}
}
Wee1 is a member of the Serine/Threonine protein kinase family and is a key regulator of cell cycle progression. It has been known that WEE1 is highly expressed and has oncogenic functions in various cancers, but it is not yet studied in gastric cancers. In this study, we investigated the oncogenic role and therapeutic potency of targeting WEE1 in gastric cancer. At first, higher expression levels of WEE1 with lower survival probability were determined in stage 4 gastric cancer patients or male… CONTINUE READING

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