Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis

@inproceedings{Ganapathy2010TargetingTT,
  title={Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis},
  author={V. Ganapathy and Rongrong Ge and Alison Grazioli and Wen Xie and Whitney A. Banach-Petrosky and Yibin Kang and Scott Lonning and John M. McPherson and Jonathan M. Yingling and Swati Biswas and Gregory R. Mundy and Michael Reiss},
  booktitle={Molecular Cancer},
  year={2010}
}
Transforming Growth Factor β (TGF-β) plays an important role in tumor invasion and metastasis. We set out to investigate the possible clinical utility of TGF-β antagonists in a human metastatic basal-like breast cancer model. We examined the effects of two types of the TGF-β pathway antagonists (1D11, a mouse monoclonal pan-TGF-β neutralizing antibody and LY2109761, a chemical inhibitor of TGF-β type I and II receptor kinases) on sublines of basal cell-like MDA-MB-231 human breast carcinoma… CONTINUE READING

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Neoplastic CellIs abnormal cell of diseasebone metastases
Besides inhibiting metastasis in a tumor cell autonomous manner , the TGF-β antagonists inhibited angiogenesis associated with lung metastases and osteoclast number and activity associated with lytic bone metastases .
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