Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies

Abstract

Mature T cell cancers are typically aggressive, treatment resistant and associated with poor prognosis. Clinical application of immunotherapeutic approaches has been limited by a lack of target antigens that discriminate malignant from healthy (normal) T cells. Unlike B cell depletion, pan–T cell aplasia is prohibitively toxic. We report a new targeting… (More)
DOI: 10.1038/nm.4444

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