Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

@article{Roberts2007TargetingTR,
  title={Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer},
  author={P. J. Roberts and Channing J Der},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={3291-3310}
}
Mitogen-activated protein kinase (MAPK) cascades are key signaling pathways involved in the regulation of normal cell proliferation, survival and differentiation. Aberrant regulation of MAPK cascades contribute to cancer and other human diseases. In particular, the extracellular signal-regulated kinase (ERK) MAPK pathway has been the subject of intense research scrutiny leading to the development of pharmacologic inhibitors for the treatment of cancer. ERK is a downstream component of an… CONTINUE READING
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