Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis

@inproceedings{Huang2018TargetingTP,
  title={Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis},
  author={Kezhen Huang and Subhajit Mukherjee and Vera M. Desmarais and Joseph M. Albanese and Ektor Rafti and Andrew Draghi and Leigh Maher and Kamal M Khanna and Sridhar Mani and Adam P. Matson},
  booktitle={Pediatric Research},
  year={2018}
}
BackgroundThere is substantial evidence that signaling through Toll-like receptor 4 (TLR4) contributes to the pathogenesis of necrotizing enterocolitis (NEC). Pregnane X receptor (PXR), a xenobiotic sensor and signaling intermediate for certain host-bacterial metabolites, has been shown to negatively regulate TLR4 signaling. Here we investigated the relationship between PXR and TLR4 in the developing murine intestine and explored the capacity of PXR to modulate inflammatory pathways involved in… CONTINUE READING
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