Targeting the PAS-A domain of HIF-1alpha for development of small molecule inhibitors of HIF-1.

@article{Park2006TargetingTP,
  title={Targeting the PAS-A domain of HIF-1alpha for development of small molecule inhibitors of HIF-1.},
  author={Eun Jung Park and Dehe Kong and Robert J. Fisher and John H. Cardellina and Robert H. Shoemaker and Giovanni Melillo},
  journal={Cell cycle},
  year={2006},
  volume={5 16},
  pages={1847-53}
}
Hypoxia inducible factor-1 (HIF-1) is a master regulator of cellular adaptation to oxygen deprivation and activates transcription of genes involved in tumor metabolism, angiogenesis, invasion and metastasis, all of which are implicated in cancer progression. Several domains of HIF-1alpha mediate protein-protein interaction, which is essential for the formation of the active heterodimer with HIF-1beta. Targeting specific domains of HIF-1alpha might lead to the identification of more selective… CONTINUE READING

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