Targeting the OB-Folds of Replication Protein A with Small Molecules

  title={Targeting the OB-Folds of Replication Protein A with Small Molecules},
  author={Victor J. Anciano Granadillo and Jennifer N. Earley and Sarah C. Shuck and Millie M Georgiadis and Richard W Fitch and John J Turchi},
  booktitle={Journal of nucleic acids},
Replication protein A (RPA) is the main eukaryotic single-strand (ss) DNA-binding protein involved in DNA replication and repair. We have identified and developed two classes of small molecule inhibitors (SMIs) that show in vitro inhibition of the RPA-DNA interaction. We present further characterization of these SMIs with respect to their target binding, mechanism of action, and specificity. Both reversible and irreversible modes of inhibition are observed for the different classes of SMIs with… CONTINUE READING
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