Targeting the Neurokinin Receptor 1 with Aprepitant: A Novel Antipruritic Strategy

  title={Targeting the Neurokinin Receptor 1 with Aprepitant: A Novel Antipruritic Strategy},
  author={Sonja St{\"a}nder and Dorothee Siepmann and Ilka Herrgott and Cord H Sunderk{\"o}tter and Thomas Anton Luger},
  booktitle={PloS one},
BACKGROUND Chronic pruritus is a global clinical problem with a high impact on the quality of life and lack of specific therapies. It is an excruciating and frequent symptom of e.g. uncurable renal, liver and skin diseases which often does not respond to conventional treatment with e.g. antihistamines. Therefore antipruritic therapies which target physiological mechanisms of pruritus need to be developed. Substance P (SP) is a major mediator of pruritus. As it binds to the neurokinin receptor 1… CONTINUE READING
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Neurobiology of Pruritus

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The impact of pruritus on the quality of life of patients undergoing dialysis: a single centre cohort study

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