Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen

@inproceedings{Qin2017TargetingTN,
  title={Targeting the NFAT1-MDM2-MDMX Network Inhibits the Proliferation and Invasion of Prostate Cancer Cells, Independent of p53 and Androgen},
  author={Jiang-jiang Qin and Xin Li and Wei Wang and Xiaolin Zi and Ruiwen Zhang},
  booktitle={Front. Pharmacol.},
  year={2017}
}
The MDM2 and MDMX oncogenes are overexpressed in various types of human cancer and are highly associated with the initiation, progression, metastasis and chemotherapeutic resistance of these diseases, including prostate cancer. The present study was designed to test a natural MDM2 inhibitor, Inulanolide A (InuA), for anti-prostate cancer activity and to… CONTINUE READING