Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia

  title={Targeting the NF-κB signaling pathway in Notch1-induced T-cell leukemia},
  author={Tomas Vilimas and Joaquina X Mascarenhas and Teresa Palomero and Malay Mandal and Silvia Buonamici and Fanling Meng and Benjamin R Thompson and Christina Spaulding and Sami Macaroun and M. D. Alegre and Barbara L Kee and Adolfo A. Ferrando and Lucio Miele and Iannis Aifantis},
  journal={Nature Medicine},
T-cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently associated with chromosomal aberrations, but it was recently shown that most individuals with T-ALL carry activating mutations in the NOTCH1 gene. However, the signaling pathways and target genes responsible for Notch1-induced neoplastic transformation remain undefined. We report here that constitutively active Notch1 activates the NF-κB pathway transcriptionally and via the IκB kinase (IKK) complex… CONTINUE READING
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