Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4

@inproceedings{Hanley2018TargetingTM,
  title={Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4},
  author={Christopher J Hanley and Massimiliano Mellone and Kirsty Ford and Steve Thirdborough and Toby Mellows and Steven J Frampton and Jr. D. Moody Smith and Elena L Harden and C{\'e}dric Szyndralewiez and Marc D. Bullock and Fergus Noble and Karwan A. Moutasim and Emma King and Pandurangan Vijayanand and Alex H. Mirnezami and Timothy J Underwood and Christian H Ottensmeier and Gareth J Thomas},
  booktitle={Journal of the National Cancer Institute},
  year={2018}
}
Background Cancer-associated fibroblasts (CAFs) are tumor-promoting and correlate with poor survival in many cancers, which has led to their emergence as potential therapeutic targets. However, effective methods to manipulate these cells clinically have yet to be developed. Methods CAF accumulation and prognostic significance in head and neck cancer (oral, n = 260; oropharyngeal, n = 271), and colorectal cancer (n = 56) was analyzed using immunohistochemistry. Mechanisms regulating fibroblast… CONTINUE READING
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